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Article

Mycotoxin Identification and In Silico Toxicity Assessment Prediction in Atlantic Salmon

Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Avenue Vicent Andrés Estellés s/n, 46100 Burjassot, Spain
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Mar. Drugs 2020, 18(12), 629; https://doi.org/10.3390/md18120629
Received: 21 November 2020 / Revised: 5 December 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
The present study aimed to identify mycotoxins in edible tissues of Atlantic salmon (Salmo salar) using liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS). After using a non-targeted screening approach and a home-made spectral library, 233 mycotoxins were analyzed. Moreover, the occurrence of mycotoxins in fish filets was evaluated, and their potential toxicity was predicted by in silico methods. According to the obtained results, forty mycotoxins were identified in analyzed salmon samples, the predominant mycotoxins being enniatins (also rugulosin and 17 ophiobolins), commonly found in cereals and their by-products. Thus, mycotoxin carry-over can occur from feed to organs and edible tissues of cultivated fish. Moreover, the toxicity of detected mycotoxins was predicted by the in silico webserver ProTox-II, highlighting that special attention must be paid to some less reported mycotoxins due to their toxic predicted properties. View Full-Text
Keywords: liquid chromatography; time of flight mass spectrometry; mycotoxins; Atlantic salmon; in silico prediction liquid chromatography; time of flight mass spectrometry; mycotoxins; Atlantic salmon; in silico prediction
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MDPI and ACS Style

Tolosa, J.; Barba, F.J.; Pallarés, N.; Ferrer, E. Mycotoxin Identification and In Silico Toxicity Assessment Prediction in Atlantic Salmon. Mar. Drugs 2020, 18, 629. https://doi.org/10.3390/md18120629

AMA Style

Tolosa J, Barba FJ, Pallarés N, Ferrer E. Mycotoxin Identification and In Silico Toxicity Assessment Prediction in Atlantic Salmon. Marine Drugs. 2020; 18(12):629. https://doi.org/10.3390/md18120629

Chicago/Turabian Style

Tolosa, Josefa, Francisco J. Barba, Noelia Pallarés, and Emilia Ferrer. 2020. "Mycotoxin Identification and In Silico Toxicity Assessment Prediction in Atlantic Salmon" Marine Drugs 18, no. 12: 629. https://doi.org/10.3390/md18120629

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