Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

Barreca, Marilia; Spanò, Virginia; Montalbano, Alessandra; Cueto, Mercedes; Díaz Marrero, Ana R.; Deniz, Irem; Erdoğan, Ayşegül; Lukić Bilela, Lada; Moulin, Corentin; Taffin-de-Givenchy, Elisabeth; Spriano, Filippo; Perale, Giuseppe; Mehiri, Mohamed; Rotter, Ana; P. Thomas, Olivier; Barraja, Paola; Gaudêncio, Susana P.; Bertoni, Francesco

doi:10.3390/md18120619

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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

Marilia Barreca

^1,2,

Virginia Spanò

¹,

Alessandra Montalbano

¹,

⁴

⁵

⁶,

⁷,

⁸,

Elisabeth Taffin-de-Givenchy

⁸,

²,

^9,10,

⁸,

¹¹

¹²

¹,

^13,*

and

Francesco Bertoni

^2,14,*

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy

Faculty of Biomedical Sciences, Institute of Oncology Research, USI, 6500 Bellinzona, Switzerland

Instituto de Productos Naturales y Agrobiología (IPNA-CSIC), La Laguna, 38206 Tenerife, Spain

⁴

Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Universidad de La Laguna (ULL), La Laguna, 38200 Tenerife, Spain

⁵

Department of Bioengineering, Faculty of Engineering, Manisa Celal Bayar University, 45119 Manisa, Turkey

⁶

Research Center for Testing and Analysis (EGE MATAL), Ege University Application, 35100 İzmir, Turkey

⁷

Department of Biology, Faculty of Science, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina

⁸

Marine Natural Products Team, UMR 7272, Institut de Chimie de Nice, Université Côte d’Azur, CNRS, 06108 Nice, France

⁹

Faculty of Biomedical Sciences, USI, 6900 Lugano, Switzerland

¹⁰

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, Austria

¹¹

Marine Biology Station Piran, National Institute of Biology, 1000 Ljubljana, Slovenia

¹²

Marine Biodiscovery Laboratory, School of Chemistry and Ryan Institute, National University of Ireland, Galway (NUI Galway), H91TK33 Galway, Ireland

¹³

UCIBIO—Applied Biomolecular Sciences Unit, Department of Chemistry, Blue Biotechnology & Biomedicine Lab, Faculty of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal

¹⁴

Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland

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Mar. Drugs 2020, 18(12), 619; https://doi.org/10.3390/md18120619

Received: 16 November 2020 / Revised: 30 November 2020 / Accepted: 2 December 2020 / Published: 4 December 2020

(This article belongs to the Collection Ocean4Biotech)

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Abstract

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use. View Full-Text

Keywords: marine natural products; marine drugs; anticancer; drug discovery; clinical pipeline

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MDPI and ACS Style

Barreca, M.; Spanò, V.; Montalbano, A.; Cueto, M.; Díaz Marrero, A.R.; Deniz, I.; Erdoğan, A.; Lukić Bilela, L.; Moulin, C.; Taffin-de-Givenchy, E.; Spriano, F.; Perale, G.; Mehiri, M.; Rotter, A.; P. Thomas, O.; Barraja, P.; Gaudêncio, S.P.; Bertoni, F. Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes. Mar. Drugs 2020, 18, 619. https://doi.org/10.3390/md18120619

AMA Style

Barreca M, Spanò V, Montalbano A, Cueto M, Díaz Marrero AR, Deniz I, Erdoğan A, Lukić Bilela L, Moulin C, Taffin-de-Givenchy E, Spriano F, Perale G, Mehiri M, Rotter A, P. Thomas O, Barraja P, Gaudêncio SP, Bertoni F. Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes. Marine Drugs. 2020; 18(12):619. https://doi.org/10.3390/md18120619

Chicago/Turabian Style

Barreca, Marilia, Virginia Spanò, Alessandra Montalbano, Mercedes Cueto, Ana R. Díaz Marrero, Irem Deniz, Ayşegül Erdoğan, Lada Lukić Bilela, Corentin Moulin, Elisabeth Taffin-de-Givenchy, Filippo Spriano, Giuseppe Perale, Mohamed Mehiri, Ana Rotter, Olivier P. Thomas, Paola Barraja, Susana P. Gaudêncio, and Francesco Bertoni. 2020. "Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes" Marine Drugs 18, no. 12: 619. https://doi.org/10.3390/md18120619

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