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Article

Bioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formats

1
Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand
2
School of Health Sciences, College of Health, Massey University, Palmerston North 4442, New Zealand
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Christchurch Clinical Studies Trust (CSST), Christchurch Central, Christchurch 8011, New Zealand
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Department of Clinical Science and Nutrition, Faculty of Medicine, Dentistry and Life Sciences, University of Chester, Chester CH1 4BJ, UK
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Department of Medicine, University of Otago, Dunedin 9016, New Zealand
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School of Food and Advanced Technology, College of Sciences, Massey University, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(11), 524; https://doi.org/10.3390/md18110524
Received: 1 September 2020 / Revised: 13 October 2020 / Accepted: 19 October 2020 / Published: 23 October 2020
Greenshell™ mussel (GSM, Perna canaliculus) is New Zealand’s most important aquaculture species. They are a good source of long chain-polyunsaturated fatty acids (n-3 LC PUFA). Beyond a traditional food product, GSMs are also sold as mussel powders and oil extract formats in the nutraceutical markets. In this study, a four-sequence, single dose, randomized crossover human trial with eight evaluable healthy male participants was undertaken to determine the bioavailability of the n-3 LC PUFA in four different GSM formats (oil, powder, food ingredient and half-shell unprocessed whole mussel) by measuring area under the curve (AUC) and maximal concentration (CMax). Blood samples were collected at baseline and up to 48 h after initiation of product consumption in each administration period. There were minor differences between the bioavailability of FA (fatty acid) between the different GSM formats. Eicosapentaenoic acid (EPA) peak concentrations and plasma exposures were significantly lower with GSM oil compared to GSM half-shell and GSM powder formats, which resulted in AUC0–48 for the intake of GSM half-shell mussel and GSM powder being significantly higher than that for GSM oil (p = 0.013, f= 4.84). This equated to a 20.6% and 24.3% increase in the amount of EPA present in the plasma after consumption of half-shell mussels and mussel powder respectively compared to GSM oil. GSM oil produced the shortest median time to maximal plasma n-3 LC PUFA concentration of all evaluated products demonstrated by a shorter maximum measured plasma concentration (TMax = 5 h). Docosahexaenoic acid (DHA) and n-3 LC PUFA plasma exposure parameters were statistically comparable across the four GSM products evaluated. View Full-Text
Keywords: eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); green lipped mussels; Perna canaliculus; pharmacokinetics eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); green lipped mussels; Perna canaliculus; pharmacokinetics
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MDPI and ACS Style

Miller, M.R.; Kruger, M.C.; Wynne, C.; Waaka, D.; Li, W.; Frampton, C.; Wolber, F.M.; Eason, C. Bioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formats. Mar. Drugs 2020, 18, 524. https://doi.org/10.3390/md18110524

AMA Style

Miller MR, Kruger MC, Wynne C, Waaka D, Li W, Frampton C, Wolber FM, Eason C. Bioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formats. Marine Drugs. 2020; 18(11):524. https://doi.org/10.3390/md18110524

Chicago/Turabian Style

Miller, Matthew R., Marlena C. Kruger, Chris Wynne, Devonie Waaka, Weili Li, Chris Frampton, Fran M. Wolber, and Charles Eason. 2020. "Bioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formats" Marine Drugs 18, no. 11: 524. https://doi.org/10.3390/md18110524

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