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Article

Antibacterial Activity of Chromomycins from a Marine-Derived Streptomyces microflavus

1
Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
2
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(10), 522; https://doi.org/10.3390/md18100522
Received: 23 September 2020 / Revised: 14 October 2020 / Accepted: 20 October 2020 / Published: 21 October 2020
A marine-derived actinomycete (Streptomyces sp. MBTI36) exhibiting antibacterial activities was investigated in the present study. The strain was identified using genetic techniques. The 16S rDNA sequence of the isolate indicated that it was most closely related to Streptomyces microflavus. Furthermore, a new chromomycin A9 (1), along with chromomycin Ap (2), chromomycin A2 (3), and chromomycin A3 (4), were isolated from the ethyl acetate extract. Their structures were determined using extensive spectroscopic methods including 1D and 2D NMR, and HRMS, as well as comparisons with previously reported data. Compounds 14 showed potent antibacterial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). During a passage experiment, minimum inhibitory concentration (MIC) values for compounds 14 showed no more than a 4-fold increase from the starting MIC value, indicating that no resistance was detected over the 21 passages. View Full-Text
Keywords: chromomycins; marine actinomycete; Streptomyces microflavus; antimicrobial activity; MRSA; resistance chromomycins; marine actinomycete; Streptomyces microflavus; antimicrobial activity; MRSA; resistance
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MDPI and ACS Style

Cho, E.; Kwon, O.-S.; Chung, B.; Lee, J.; Sun, J.; Shin, J.; Oh, K.-B. Antibacterial Activity of Chromomycins from a Marine-Derived Streptomyces microflavus. Mar. Drugs 2020, 18, 522. https://doi.org/10.3390/md18100522

AMA Style

Cho E, Kwon O-S, Chung B, Lee J, Sun J, Shin J, Oh K-B. Antibacterial Activity of Chromomycins from a Marine-Derived Streptomyces microflavus. Marine Drugs. 2020; 18(10):522. https://doi.org/10.3390/md18100522

Chicago/Turabian Style

Cho, Eunji, Oh-Seok Kwon, Beomkoo Chung, Jayho Lee, Jeongyoon Sun, Jongheon Shin, and Ki-Bong Oh. 2020. "Antibacterial Activity of Chromomycins from a Marine-Derived Streptomyces microflavus" Marine Drugs 18, no. 10: 522. https://doi.org/10.3390/md18100522

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