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Open AccessArticle

Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

1
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China
2
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 433; https://doi.org/10.3390/md17080433
Received: 12 June 2019 / Revised: 13 July 2019 / Accepted: 22 July 2019 / Published: 24 July 2019
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Abstract

Three new lactones penicilactones A−C (13) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo2(OAc)4-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC50 value of 78.5 (±0.58) μg/mL. View Full-Text
Keywords: Penicillium sp.; lactones; antibacterial activity; insecticidal activity Penicillium sp.; lactones; antibacterial activity; insecticidal activity
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Bai, M.; Huang, G.-L.; Mei, R.-Q.; Wang, B.; Luo, Y.-P.; Nong, X.-H.; Chen, G.-Y.; Zheng, C.-J. Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112. Mar. Drugs 2019, 17, 433.

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