Costatone C—A New Halogenated Monoterpene from the New Zealand Red Alga Plocamium angustum
AbstractRed algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the planar structure of 7 was achieved through conventional NMR and (−)-HR-APCI-MS techniques, and the absolute configuration by comparison of experimental and DFT-calculated ECD spectra. The absolute configuration of 8 was determined using Mosher’s method. Compound 7 showed mild antibacterial activity against Staphylococcus aureus and S. epidermidis. The state of Plocamium taxonomy and its implications upon natural product distributions, especially across samples from specimens collected in different countries, is also discussed. View Full-Text
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Bracegirdle, J.; Sohail, Z.; Fairhurst, M.J.; Gerth, M.L.; Zuccarello, G.C.; Ali Hashmi, M.; Keyzers, R.A. Costatone C—A New Halogenated Monoterpene from the New Zealand Red Alga Plocamium angustum. Mar. Drugs 2019, 17, 418.
Bracegirdle J, Sohail Z, Fairhurst MJ, Gerth ML, Zuccarello GC, Ali Hashmi M, Keyzers RA. Costatone C—A New Halogenated Monoterpene from the New Zealand Red Alga Plocamium angustum. Marine Drugs. 2019; 17(7):418.Chicago/Turabian Style
Bracegirdle, Joe; Sohail, Zaineb; Fairhurst, Michael J.; Gerth, Monica L.; Zuccarello, Giuseppe C.; Ali Hashmi, Muhammad; Keyzers, Robert A. 2019. "Costatone C—A New Halogenated Monoterpene from the New Zealand Red Alga Plocamium angustum." Mar. Drugs 17, no. 7: 418.
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