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Terrosamycins A and B, Bioactive Polyether Ionophores from Streptomyces sp. RKND004 from Prince Edward Island Sediment

1
Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
2
Nautilus Biosciences Croda, 550 University Avenue, Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
3
Department of Chemistry, University of New Brunswick, 30 Dineen Drive, Fredericton, NB E3B 5A3, Canada
4
Department of Biomedical Science, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Prince Edward Island, Charlottetown, PE C1A 4P3 Canada
5
Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 347; https://doi.org/10.3390/md17060347
Received: 23 May 2019 / Revised: 5 June 2019 / Accepted: 7 June 2019 / Published: 11 June 2019
Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of these compounds. The structure of 1 was determined from analysis of NMR, HRMS, and X-ray diffraction data. NMR experiments performed on 2 revealed the presence of two methoxy groups replacing two hydroxy groups in 1. Like other polyether ionophores, 1 and 2 exhibited excellent antibiotic activity against Gram-positive pathogens. Interestingly, the terrosamycins also exhibited activity against two breast cancer cell lines. View Full-Text
Keywords: Streptomyces; polycyclic polyether; marine sediment; X-ray diffraction; antibiotic; metabolomics Streptomyces; polycyclic polyether; marine sediment; X-ray diffraction; antibiotic; metabolomics
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Sproule, A.; Correa, H.; Decken, A.; Haltli, B.; Berrué, F.; Overy, D.P.; Kerr, R.G. Terrosamycins A and B, Bioactive Polyether Ionophores from Streptomyces sp. RKND004 from Prince Edward Island Sediment. Mar. Drugs 2019, 17, 347.

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