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Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence

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DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305-8565, Japan
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School of Integrative & Global Majors, University of Tsukuba, Tsukuba 305-8577, Japan
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DAILAB, Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi 110-016, India
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 338; https://doi.org/10.3390/md17060338
Received: 15 May 2019 / Revised: 30 May 2019 / Accepted: 31 May 2019 / Published: 5 June 2019
Fucoxanthin is commonly found in marine organisms; however, to date, it has been one of the scarcely explored natural compounds. We investigated its activities in human cancer cell culture-based viability, migration, and molecular assays, and found that it possesses strong anticancer and anti-metastatic activities that work irrespective of the p53 status of cancer cells. In our experiments, fucoxanthin caused the transcriptional suppression of mortalin. Cell phenotype-driven molecular analyses on control and treated cells demonstrated that fucoxanthin caused a decrease in hallmark proteins associated with cell proliferation, survival, and the metastatic spread of cancer cells at doses that were relatively safe to the normal cells. The data suggested that the cancer therapy regimen may benefit from the recruitment of fucoxanthin; hence, it warrants further attention for basic mechanistic studies as well as drug development. View Full-Text
Keywords: fucoxanthin; cancer; p53–mortalin interaction; abrogation; growth arrest; therapy fucoxanthin; cancer; p53–mortalin interaction; abrogation; growth arrest; therapy
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Garg, S.; Afzal, S.; Elwakeel, A.; Sharma, D.; Radhakrishnan, N.; Dhanjal, J.K.; Sundar, D.; Kaul, S.C.; Wadhwa, R. Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence. Mar. Drugs 2019, 17, 338.

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