Next Article in Journal
Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway
Previous Article in Journal
The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain
Article Menu

Export Article

Open AccessArticle

Curdepsidones B–G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
*
Authors to whom correspondence should be addressed.
These authors equally contribute to this work.
Mar. Drugs 2019, 17(5), 266; https://doi.org/10.3390/md17050266
Received: 18 April 2019 / Revised: 29 April 2019 / Accepted: 2 May 2019 / Published: 5 May 2019
  |  
PDF [2962 KB, uploaded 5 May 2019]
  |     |  

Abstract

Six new depsidones, curdepsidones B–G (16), were obtained from the marine-derived fungus Curvularia sp. IFB-Z10. Their planar structures were determined by comprehensive analysis of HRESIMS and 1D/2D-NMR data. The absolute configuration of curdepsidones B–C (12) were established by synergistic use of DFT/NMR (density functional theory/nuclear magnetic resonance) and TDDFT/ECD (time-dependent density functional theory/electronic circular dichroism) calculations. Partial isolated compounds were tested for their anti-inflammatory activities in Propionibacterium acnes-induced THP-1 cells. Curdepsidone C (2) displayed significant anti-inflammatory properties with an IC50 value of 7.47 ± 0.35 μM, and reduced the P. acnes-induced phosphorylation levels of JNK and ERK in a dose-dependent mechanism. The possible anti-inflammatory mechanism of 2 was also investigated by molecular docking. View Full-Text
Keywords: marine-derived fungus; Curvularia sp. IFB-Z10; depsidones; ECD calculation; anti-inflammatory activity; Propionibacterium acnes marine-derived fungus; Curvularia sp. IFB-Z10; depsidones; ECD calculation; anti-inflammatory activity; Propionibacterium acnes
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Ding, Y.; An, F.; Zhu, X.; Yu, H.; Hao, L.; Lu, Y. Curdepsidones B–G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10. Mar. Drugs 2019, 17, 266.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top