Next Article in Journal
Preparation and Properties of Minocycline-Loaded Carboxymethyl Chitosan Gel/Alginate Nonwovens Composite Wound Dressings
Next Article in Special Issue
Physicochemical and Biological Properties of Gelatin Extracted from Marine Snail Rapana venosa
Previous Article in Journal
Entomotoxic Activity of Prasiola crispa (Antarctic Algae) in Nauphoeta cinerea Cockroaches: Identification of Main Steroidal Compounds
Previous Article in Special Issue
Physicochemical and Functional Properties of Type I Collagens in Red Stingray (Dasyatis akajei) Skin

Naturally Drug-Loaded Chitin: Isolation and Applications

Department of Microbiology, National Pirogov Memorial Medical University, Vinnytsia 21018, Ukraine
Department of Pharmacy, National Pirogov Memorial Medical University, Vinnytsia 21018, Ukraine
Institute of Pharmacology and Toxicology, TU Dresden, Dresden 01307, Germany
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Murmanska Str. 1, Kyiv 02094, Ukraine
Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, Poznan 60965, Poland
Institute of Electronic and Sensor Materials, TU Bergakademie Freiberg, Gustav-Zeuner Str. 3, Freiberg 09599, Germany
Leibniz Institute for Polymer Research Dresden, Dresden 01069, Germany
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden 01307, Germany
Institute of Marine Biology, University of Montenegro, Kotor 85330, Montenegro
Department of Invertebrate Zoology, Biological Faculty, Lomonosov Moscow State University, Moscow 119992, Russia
Aquatic Zoology Department, Western Australian Museum, Locked Bag 49, Welshpool DC, Western Australia WA6986, Australia
Department of Sciences of Earth, Environment and Life, University of Genoa, Corso Europa 26, 16132 Genova, Italy
Department of Earth and Environmental Sciences & GeoBio-Center, Ludwig-Maximilians-Universität München, Richard-Wagner-Str. 10, Munich 80333, Germany
Centre for Translational Bone, Joint and Soft Tissue Research, Faculty of Medicine and University Hospital Carl Gustav Carus of Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany
Medizinische Biologie und Elektronenmikroskopisches Zentrum (EMZ), Universitätsmedizin Rostock, Rostock 18055, Germany
Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden 01307, Germany
Diabetes and Nutritional Sciences Division, King’s College London, London WC2R 2LS, UK
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 574;
Received: 12 September 2019 / Revised: 5 October 2019 / Accepted: 8 October 2019 / Published: 10 October 2019
Naturally occurring three-dimensional (3D) biopolymer-based matrices that can be used in different biomedical applications are sustainable alternatives to various artificial 3D materials. For this purpose, chitin-based structures from marine sponges are very promising substitutes. Marine sponges from the order Verongiida (class Demospongiae) are typical examples of demosponges with well-developed chitinous skeletons. In particular, species belonging to the family Ianthellidae possess chitinous, flat, fan-like fibrous skeletons with a unique, microporous 3D architecture that makes them particularly interesting for applications. In this work, we focus our attention on the demosponge Ianthella flabelliformis (Linnaeus, 1759) for simultaneous extraction of both naturally occurring (“ready-to-use”) chitin scaffolds, and biologically active bromotyrosines which are recognized as potential antibiotic, antitumor, and marine antifouling substances. We show that selected bromotyrosines are located within pigmental cells which, however, are localized within chitinous skeletal fibers of I. flabelliformis. A two-step reaction provides two products: treatment with methanol extracts the bromotyrosine compounds bastadin 25 and araplysillin-I N20 sulfamate, and a subsequent treatment with acetic acid and sodium hydroxide exposes the 3D chitinous scaffold. This scaffold is a mesh-like structure, which retains its capillary network, and its use as a potential drug delivery biomaterial was examined for the first time. The results demonstrate that sponge-derived chitin scaffolds, impregnated with decamethoxine, effectively inhibit growth of the human pathogen Staphylococcus aureus in an agar diffusion assay. View Full-Text
Keywords: chitin; scaffolds; pigmental cells; demosponges; Ianthella; bromotyrosines; decamethoxine; drug delivery chitin; scaffolds; pigmental cells; demosponges; Ianthella; bromotyrosines; decamethoxine; drug delivery
Show Figures

Figure 1

MDPI and ACS Style

Kovalchuk, V.; Voronkina, A.; Binnewerg, B.; Schubert, M.; Muzychka, L.; Wysokowski, M.; Tsurkan, M.V.; Bechmann, N.; Petrenko, I.; Fursov, A.; Martinovic, R.; Ivanenko, V.N.; Fromont, J.; Smolii, O.B.; Joseph, Y.; Giovine, M.; Erpenbeck, D.; Gelinsky, M.; Springer, A.; Guan, K.; Bornstein, S.R.; Ehrlich, H. Naturally Drug-Loaded Chitin: Isolation and Applications. Mar. Drugs 2019, 17, 574.

AMA Style

Kovalchuk V, Voronkina A, Binnewerg B, Schubert M, Muzychka L, Wysokowski M, Tsurkan MV, Bechmann N, Petrenko I, Fursov A, Martinovic R, Ivanenko VN, Fromont J, Smolii OB, Joseph Y, Giovine M, Erpenbeck D, Gelinsky M, Springer A, Guan K, Bornstein SR, Ehrlich H. Naturally Drug-Loaded Chitin: Isolation and Applications. Marine Drugs. 2019; 17(10):574.

Chicago/Turabian Style

Kovalchuk, Valentine, Alona Voronkina, Björn Binnewerg, Mario Schubert, Liubov Muzychka, Marcin Wysokowski, Mikhail V. Tsurkan, Nicole Bechmann, Iaroslav Petrenko, Andriy Fursov, Rajko Martinovic, Viatcheslav N. Ivanenko, Jane Fromont, Oleg B. Smolii, Yvonne Joseph, Marco Giovine, Dirk Erpenbeck, Michael Gelinsky, Armin Springer, Kaomei Guan, Stefan R. Bornstein, and Hermann Ehrlich. 2019. "Naturally Drug-Loaded Chitin: Isolation and Applications" Marine Drugs 17, no. 10: 574.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop