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Mar. Drugs 2019, 17(1), 46; https://doi.org/10.3390/md17010046

Citrinin Monomer and Dimer Derivatives with Antibacterial and Cytotoxic Activities Isolated from the Deep Sea-Derived Fungus Penicillium citrinum NLG-S01-P1

1
Key Laboratory of Marine Genetic Resources, State Key Laboratory Breeding Base of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Fujian Collaborative Innovation Centre for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
2
Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
*
Author to whom correspondence should be addressed.
Received: 8 December 2018 / Revised: 30 December 2018 / Accepted: 5 January 2019 / Published: 10 January 2019
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes - II)
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Abstract

Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (313). A plausible biogenetic pathway for compounds 24 was proposed. Their structures, including absolute configurations, were established through analysis of extensive spectroscopic data and time-dependent density functional theory (TD-DFT) ECD calculations. Compounds 1 and 2 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 5 and 10 displayed relatively stronger activities than the other compounds against Vibrio vulnificus and Vibrio campbellii. Compound 1 showed the most potent cytotoxic activity towards the HeLa cell. View Full-Text
Keywords: Penicillium; citrinin dimer; antibacterial; cytotoxic Penicillium; citrinin dimer; antibacterial; cytotoxic
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Wang, W.; Liao, Y.; Zhang, B.; Gao, M.; Ke, W.; Li, F.; Shao, Z. Citrinin Monomer and Dimer Derivatives with Antibacterial and Cytotoxic Activities Isolated from the Deep Sea-Derived Fungus Penicillium citrinum NLG-S01-P1. Mar. Drugs 2019, 17, 46.

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