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Mar. Drugs 2019, 17(1), 21; https://doi.org/10.3390/md17010021

Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative

1
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
2
College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
*
Author to whom correspondence should be addressed.
Received: 13 December 2018 / Revised: 23 December 2018 / Accepted: 26 December 2018 / Published: 1 January 2019
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Abstract

Polysaccharide chromium (III) derivatives are gaining increasing attention in improving type 2 diabetes. In this study, the sulfated polysaccharide from Enteromorpha prolifera (SPE) with 4.8 kDa was prepared by specific enzymatic hydrolysis. The obtained SPE was used to prepare a rhamnan-type sulfated polysaccharide derivative (SPED). Results indicated that O-H, C=O, and S=O were effectively involved in the chelation of SPED (chromium content 20.26%). Acute (half lethal dose > 2.38 g/kg) and sub-acute toxicity showed that SPED had no damaging effects on mice. Anti-diabetic experiment demonstrated that SPED improved glucose metabolism. Moreover, SPED promoted the PI3K/PKB/GSK-3β signaling pathway by regulating mRNA expression of insulin receptors (IR), insulin receptor substrate 2 (IRS-2), phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB), and glycogen synthase kinase 3β (GSK-3β). In conclusion, the SPED might represent a novel marine-derived candidate against hyperglycemia, which may undergo further pharmaceutical development as a hypoglycemic agent. View Full-Text
Keywords: sulfated polysaccharide derivative; structure characterization; safety evaluation; type 2 diabetes; molecular mechanism sulfated polysaccharide derivative; structure characterization; safety evaluation; type 2 diabetes; molecular mechanism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cui, J.-F.; Ye, H.; Zhu, Y.-J.; Li, Y.-P.; Wang, J.-F.; Wang, P. Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative. Mar. Drugs 2019, 17, 21.

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