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Mar. Drugs 2019, 17(1), 19;

Natural Product Repertoire of the Genus Amphimedon

Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, P.O. Box 61111 New Minia City, 61519 Minia, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudingerweg 5, 55128 Mainz, Germany
Authors to whom correspondence should be addressed.
Received: 25 November 2018 / Revised: 20 December 2018 / Accepted: 24 December 2018 / Published: 30 December 2018
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Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associated microbiota, along with their corresponding biological activities, whenever applicable. View Full-Text
Keywords: marine natural products; sponges; Amphimedon; alkaloids; ceramides; bacteria marine natural products; sponges; Amphimedon; alkaloids; ceramides; bacteria

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Shady, N.H.; Fouad, M.A.; Salah Kamel, M.; Schirmeister, T.; Abdelmohsen, U.R. Natural Product Repertoire of the Genus Amphimedon. Mar. Drugs 2019, 17, 19.

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