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Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics
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Metabolic and Biosynthetic Diversity in Marine Myxobacteria

Department of Microbial Natural Products (MINS), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)—Helmholtz Centre for Infection Research (HZI), Campus E8 1, 66123 Saarbrücken, Germany
German Center for Infection Research (DZIF), Partner site Hannover-Braunschweig, Inhoffenstr. 7, 38124 Braunschweig, Germany
Xenobe Research Institute, P.O. Box 3052, San Diego, CA 92163-1052, USA
Department of Pharmacy, Saarland University, Campus E8 1, 66123 Saarbrücken, Germany
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(9), 314;
Received: 31 July 2018 / Revised: 24 August 2018 / Accepted: 30 August 2018 / Published: 5 September 2018
(This article belongs to the Special Issue Marine Myxobacteria: Sea Secrets from the Slime)
Prior to 2005, the vast majority of characterized myxobacteria were obtained from terrestrial habitats. Since then, several species of halotolerant and even obligate marine myxobacteria have been described. Chemical analyses of extracts from these organisms have confirmed their ability to produce secondary metabolites with unique chemical scaffolds. Indeed, new genera of marine-derived myxobacteria, particularly Enhygromyxa, have been shown to produce novel chemical scaffolds that differ from those observed in soil myxobacteria. Further studies have shown that marine sponges and terrestrial myxobacteria are capable of producing similar or even identical secondary metabolites, suggesting that myxobacterial symbionts may have been the true producers. Recent in silico analysis of the genome sequences available from six marine myxobacteria disclosed a remarkably versatile biosynthetic potential. With access to ever-advancing tools for small molecule and genetic evaluation, these studies suggest a bright future for expeditions into this yet untapped resource for secondary metabolites. View Full-Text
Keywords: marine myxobacteria; natural products; secondary metabolism; biosynthesis; genomics; diversity marine myxobacteria; natural products; secondary metabolism; biosynthesis; genomics; diversity
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Gemperlein, K.; Zaburannyi, N.; Garcia, R.; La Clair, J.J.; Müller, R. Metabolic and Biosynthetic Diversity in Marine Myxobacteria. Mar. Drugs 2018, 16, 314.

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