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Mar. Drugs 2018, 16(5), 152; https://doi.org/10.3390/md16050152

Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems

1
Department of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
2
Institut de Chimie des Substances Naturelles ICSN, Centre National de la Recherche Scientifique, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France
3
iMARE natural S.L. Avda. Habana, 10, 18600 Motril, Spain
*
Author to whom correspondence should be addressed.
Received: 3 April 2018 / Revised: 28 April 2018 / Accepted: 4 May 2018 / Published: 6 May 2018
(This article belongs to the Special Issue Isolation and Structure Elucidation of Marine Secondary Metabolites)
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Abstract

Isolation of marine compounds from living invertebrates represents a major challenge for sustainable and environmentally friendly exploitation of marine bio-resources. To develop innovative technology to trap invertebrate compounds in the open sea, the proof of concept of a system combining external continuous circulation of water with XAD-amberlite solid-phase extraction was validated in an aquarium. In this work, we reported the elicitation of guanidine alkaloid production of Crambe crambe in the presence of Anemonia sulcata, both collected from the Mediterranean Sea. Besides the previously reported crambescidin 359 (1), and crambescidin acid (2), three new compounds were isolated; one carboxylated analog of 1 named crambescidin 401 (3), and two analogs of crambescin B, crambescin B 281 (4) and crambescin B 253 (5). Based on these results, a technology named Somartex® for “Self Operating MARine Trapping Extractor” was patented and built to transfer the concept from closed aquarium systems to open marine ecosystems. View Full-Text
Keywords: Crambe crambe; solid-phase extraction; guanidine alkaloids; crambescidins and crambescins; Somartex Crambe crambe; solid-phase extraction; guanidine alkaloids; crambescidins and crambescins; Somartex
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Vlachou, P.; Le Goff, G.; Alonso, C.; Álvarez, P.A.; Gallard, J.-F.; Fokialakis, N.; Ouazzani, J. Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems. Mar. Drugs 2018, 16, 152.

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