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Mar. Drugs 2018, 16(4), 102;

Unique Collagen Fibers for Biomedical Applications

Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
The Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Authors to whom correspondence should be addressed.
Received: 15 February 2018 / Revised: 9 March 2018 / Accepted: 17 March 2018 / Published: 23 March 2018
(This article belongs to the Special Issue Collagen from Marine Biological Source and Medical Applications)
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The challenge to develop grafts for tissue regeneration lies in the need to obtain a scaffold that will promote cell growth in order to form new tissue at a trauma-damaged site. Scaffolds also need to provide compatible mechanical properties that will support the new tissue and facilitate the desired physiological activity. Here, we used natural materials to develop a bio-composite made of unique collagen embedded in an alginate hydrogel material. The collagen fibers used to create the building blocks exhibited a unique hyper-elastic behavior similar to that of natural human tissue. The prominent mechanical properties, along with the support of cell adhesion affects cell shape and supports their proliferation, consequently facilitating the formation of a new tissue-like structure. The current study elaborates on these unique collagen fibers, focusing on their structure and biocompatibility, in an in vitro model. The findings suggest it as a highly appropriate material for biomedical applications. The promising in vitro results indicate that the distinctive collagen fibers could serve as a scaffold that can be adapted for tissue regeneration, in support of healing processes, along with maintaining tissue mechanical properties for the new regenerate tissue formation. View Full-Text
Keywords: marine biomaterials; medical device; scaffold; soft corals; tissue regeneration marine biomaterials; medical device; scaffold; soft corals; tissue regeneration

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Benayahu, D.; Sharabi, M.; Pomeraniec, L.; Awad, L.; Haj-Ali, R.; Benayahu, Y. Unique Collagen Fibers for Biomedical Applications. Mar. Drugs 2018, 16, 102.

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