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Mar. Drugs 2018, 16(3), 93; https://doi.org/10.3390/md16030093

Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Lobophytum michaelae

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada
4
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
5
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
6
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
7
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
8
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
9
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
11
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 January 2018 / Revised: 8 March 2018 / Accepted: 9 March 2018 / Published: 13 March 2018
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Abstract

Three new polyoxygenated steroids, michosterols A–C (13), and four known compounds (47) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and comparison of the nuclear magnetic resonance (NMR) data with related steroids. The cytotoxicity of compounds 13 against the proliferation of a limited panel of cancer cell lines was assayed. Compound 1 was found to display moderate cytotoxicity against adenocarcinomic human alveolar basal epithelial (A549) cancer cells. It also exhibited potent anti-inflammatory activity by suppressing superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-stimulated human neutrophils. Furthermore, 3 could effectively inhibit elastase release, as well. View Full-Text
Keywords: soft coral; Lobophytum michaelae; cytotoxicity; anti-inflammatory activity soft coral; Lobophytum michaelae; cytotoxicity; anti-inflammatory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Huang, C.-Y.; Tseng, W.-R.; Ahmed, A.F.; Chiang, P.-L.; Tai, C.-J.; Hwang, T.-L.; Dai, C.-F.; Sheu, J.-H. Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Lobophytum michaelae. Mar. Drugs 2018, 16, 93.

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