Next Article in Journal
Comparative Analysis of Culture Conditions for the Optimization of Carotenoid Production in Several Strains of the Picoeukaryote Ostreococcus
Next Article in Special Issue
Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Lobophytum michaelae
Previous Article in Journal / Special Issue
Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Mar. Drugs 2018, 16(3), 75;

Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum

Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
Planning & Research Division, National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, 75123 Uppsala, Sweden
Greenhouse Systems Technology Center, Central Region Campus, Industrial Technology Research Institute, Nantou 54041, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei 11529, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Authors to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 1 February 2018 / Accepted: 23 February 2018 / Published: 27 February 2018
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
Full-Text   |   PDF [3491 KB, uploaded 27 February 2018]   |  


Four new briarane diterpenoids, briaviolides K–N (14), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 14 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages. View Full-Text
Keywords: Briareum violaceum; briarane; briaviolide; iNOS; COX-2; ChemGPS-NP Briareum violaceum; briarane; briaviolide; iNOS; COX-2; ChemGPS-NP

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Xu, J.-H.; Lai, K.-H.; Su, Y.-D.; Chang, Y.-C.; Peng, B.-R.; Backlund, A.; Wen, Z.-H.; Sung, P.-J. Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum. Mar. Drugs 2018, 16, 75.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top