Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
1
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
3
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this paper.
Mar. Drugs 2018, 16(2), 71; https://doi.org/10.3390/md16020071
Received: 19 December 2017 / Revised: 12 February 2018 / Accepted: 13 February 2018 / Published: 22 February 2018
A new hybrid polyketide, cladodionen (1), together with a new abscisic acid analogue, cladosacid (2), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen (1) showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC50 values of 18.7, 19.1, 17.9, and 9.1 µM.
View Full-Text
Keywords:
marine-derived fungus; Cladosporium sp. OUCMDZ-1635; polyketide; cladodionen; cladosacid; cytotoxicities
▼
Show Figures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
- Supplementary File 1:
PDF-Document (PDF, 2956 KiB)
MDPI and ACS Style
Zhu, G.; Kong, F.; Wang, Y.; Fu, P.; Zhu, W. Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635. Mar. Drugs 2018, 16, 71. https://doi.org/10.3390/md16020071
AMA Style
Zhu G, Kong F, Wang Y, Fu P, Zhu W. Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635. Marine Drugs. 2018; 16(2):71. https://doi.org/10.3390/md16020071
Chicago/Turabian StyleZhu, Guoliang; Kong, Fandong; Wang, Yi; Fu, Peng; Zhu, Weiming. 2018. "Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635" Mar. Drugs 16, no. 2: 71. https://doi.org/10.3390/md16020071
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit