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Mar. Drugs 2018, 16(12), 474; https://doi.org/10.3390/md16120474

Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus

1
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand
2
Chulabhorn Graduate Institute, Chemical Biology Program, Chulabhorn Royal Academy, Kamphaeng Phet 6 Rood, Bangkok 10210, Thailand
3
Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Phuket 83000, Thailand
4
Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok 10210, Thailand
*
Author to whom correspondence should be addressed.
Received: 30 October 2018 / Revised: 23 November 2018 / Accepted: 24 November 2018 / Published: 28 November 2018
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Abstract

Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6Z)-neomanoalide-24-acetate, two diastereomers of 24-O-methylmanoalide, luffariolide B, manoalide, (6E)- and (6Z)-neomanoalide, seco-manoalide, scalarafuran, 12-acetylscalarolide, 12-epi-O-deacetyl-19-deoxyscalarin, 12-epi-scalarin, and 12-O-deacetyl-12-epi-scalarin, three indole alkaloids, 5-hydroxy-1H-indole-3-carbaldehyde, hyrtiosine A, and variabine B, and one norterpene, cavernosine were isolated from the marine sponge Hyrtios erectus. Their structures were determined by means of spectroscopic methods and the absolute configurations of the asymmetric centers were determined using the modified Mosher’s method. The cytotoxic activities for the isolated compounds have been reported. View Full-Text
Keywords: Hyrtios erectus (CRI 572 and CRI 588); Thorectidae; manoalides; scalarane; 2-furanone derivatives; cytotoxic activities Hyrtios erectus (CRI 572 and CRI 588); Thorectidae; manoalides; scalarane; 2-furanone derivatives; cytotoxic activities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kaweetripob, W.; Mahidol, C.; Tuntiwachwuttikul, P.; Ruchirawat, S.; Prawat, H. Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus. Mar. Drugs 2018, 16, 474.

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