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Mar. Drugs 2018, 16(12), 468; https://doi.org/10.3390/md16120468

Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66

1
Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
2
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
These authors contributed equally to this paper.
*
Authors to whom correspondence should be addressed.
Received: 5 November 2018 / Revised: 21 November 2018 / Accepted: 21 November 2018 / Published: 26 November 2018
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Abstract

Five new compounds named asperpenes A-C (13), 12,13-dedihydroversiol (4), and methyl 6-oxo-3,6-dihydro-2H-pyran-4-carboxylate (5), along with 10 known compounds (615), were isolated from the fermentation broth of Aspergillus sp. SCS-KFD66 associated with a bivalve mollusk, Sanguinolaria chinensis, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538, Listeria monocytogenes ATCC 1911, and Bacillus subtilis ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated. View Full-Text
Keywords: marine-derived fungus; Aspergillus sp.; secondary metabolites; antibacterial activity marine-derived fungus; Aspergillus sp.; secondary metabolites; antibacterial activity
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An, C.-L.; Kong, F.-D.; Ma, Q.-Y.; Xie, Q.-Y.; Yuan, J.-Z.; Zhou, L.-M.; Dai, H.-F.; Yu, Z.-F.; Zhao, Y.-X. Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66. Mar. Drugs 2018, 16, 468.

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