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Mar. Drugs 2018, 16(11), 407; https://doi.org/10.3390/md16110407

The Anemonia viridis Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research

1
National Research Council-Institute for the Study of Anthropogenic Impacts and Sustainability in the Marine Environment (IAS-CNR), Laboratory of Molecular Ecology and Biotechnology, Capo Granitola, Via del mare, Campobello di Mazara (TP), 91021 Sicily, Italy
2
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, GSP-7, ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia
3
Department of Earth and Marine Sciences, University of Palermo, 90100 Palermo, Italy
4
Istituto di Biomedicina e di Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy
5
Institute of Molecular Medicine, Ministry of Healthcare of the Russian Federation, Sechenov First Moscow State Medical University, 119991 Moscow, Russia
These authors have made equal contribution.
*
Authors to whom correspondence should be addressed.
Received: 29 September 2018 / Revised: 20 October 2018 / Accepted: 24 October 2018 / Published: 25 October 2018
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Abstract

Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops. Strikingly, cnidaria are considered as sustainable resources for this purpose, as they possess unique cells for attack and protection, producing an articulated cocktail of bioactive substances. The Mediterranean sea anemone Anemonia viridis has been studied extensively for years. In this short review, we summarize advances in bioprospecting of the A. viridis toxin arsenal. A. viridis RNA datasets and toxin data mining approaches are briefly described. Analysis reveals the major pool of neurotoxins of A. viridis, which are particularly active on sodium and potassium channels. This review therefore integrates progress in both RNA-Seq based and biochemical-based bioprospecting of A. viridis toxins for biotechnological exploitation. View Full-Text
Keywords: transcriptomics; bio-prospecting; computational biology; neurotoxins transcriptomics; bio-prospecting; computational biology; neurotoxins
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Nicosia, A.; Mikov, A.; Cammarata, M.; Colombo, P.; Andreev, Y.; Kozlov, S.; Cuttitta, A. The Anemonia viridis Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research. Mar. Drugs 2018, 16, 407.

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