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Open AccessArticle

Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Department of Biochemistry, University of Toronto, Toronto, ON M5G2R3, Canada
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Author to whom correspondence should be addressed.
Mar. Drugs 2017, 15(9), 280;
Received: 11 August 2017 / Revised: 29 August 2017 / Accepted: 30 August 2017 / Published: 1 September 2017
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
PDF [1648 KB, uploaded 3 September 2017]


A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-D-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities. View Full-Text
Keywords: soft coral; Sinularia brassica; steroid; cytotoxic activity; anti-inflammatory activity soft coral; Sinularia brassica; steroid; cytotoxic activity; anti-inflammatory activity

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Huang, C.-Y.; Su, J.-H.; Liaw, C.-C.; Sung, P.-J.; Chiang, P.-L.; Hwang, T.-L.; Dai, C.-F.; Sheu, J.-H. Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank. Mar. Drugs 2017, 15, 280.

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