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Mar. Drugs 2017, 15(7), 222;

Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity

Laboratoire de Biotechnologie et Chimie Marines, Institut Universitaire Européen de la Mer, Université de Bretagne-Sud, 56100 Lorient, France
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany
Plymouth Marine Laboratory, Plymouth PL1 3DH, UK
Biodimar, LEMAR UMR 6539, Institut Européen de la Mer, Université de Bretagne Occidentale, 29200 Brest, France
Author to whom correspondence should be addressed.
Received: 2 June 2017 / Revised: 29 June 2017 / Accepted: 6 July 2017 / Published: 12 July 2017
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Since the banning of several families of compounds in antifouling (AF) coatings, the search for environmentally friendly AF compounds has intensified. Natural sources of AF compounds have been identified in marine organisms and can be used to create analogues in laboratory. In a previous study, we identified that dibromohemibastadin-1 (DBHB) is a promising AF molecule, leading to the inhibition of the activity of phenoloxidase, an enzyme involved in the attachment of mussels to surfaces. This paper describes the activity of the DBHB on biofilm formation and its detachment and on bacterial adhesion and communication: quorum sensing. DBHB has an anti-biofilm activity without affecting adhesion of marine and terrestrial bacteria at a dose of 10 µM. Moreover, DBHB activity on quorum sensing (QS) is demonstrated at doses of 8 and 16 µM. The activity of DBHB on QS is compared to kojic acid, a quorum sensing inhibitor already described. This compound is a promising environmentally friendly molecule potentially useful for the inhibition of microfouling. View Full-Text
Keywords: biofouling; biofilm; bastadin derivative; microfouling; quorum sensing; sponge biofouling; biofilm; bastadin derivative; microfouling; quorum sensing; sponge

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Le Norcy, T.; Niemann, H.; Proksch, P.; Tait, K.; Linossier, I.; Réhel, K.; Hellio, C.; Faÿ, F. Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity. Mar. Drugs 2017, 15, 222.

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