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Perna canaliculus and the Intestinal Microbiome

Sydney Medical School, The University of Sydney, Sydney 17200, Australia
Medlab Clinical, Sydney 17200, Australia
Author to whom correspondence should be addressed.
Mar. Drugs 2017, 15(7), 207;
Received: 1 June 2017 / Revised: 21 June 2017 / Accepted: 26 June 2017 / Published: 30 June 2017
(This article belongs to the Special Issue Nutraceuticals and Functional Foods)
Natural medicines are often an attractive option for patients diagnosed with chronic conditions. Three main classes of bioactives that have been reported from marine mussel extracts include proteins, lipids and carbohydrates. Commercially, the most relevant species of marine mollusks belong to two genera, Perna and Mytilus. Specifically, the Perna canaliculus species has been repeatedly demonstrated to harbor anti-inflammatory compounds such as omega-3 polyunsaturated fatty acids (ω-3 PUFAs) that can ameliorate pro-inflammatory conditions, or proteins that can promote thrombin inhibitory activity. Recent clinical studies have posited that extracts from green-lipped mussels may lead to prebiotic activity in the intestinal microbiome that in turn has been reported to improve symptoms of osteoarthritis of the knee. Prebiotics have been reported to favorably interact with the intestinal microbiome through the proliferation of beneficial bacteria in the gut, suppressing exogenous and endogenous intestinal infections and promoting homeostasis by balancing local pro- and anti-inflammatory actions. Bioactive compounds from Perna canaliculus are functional foods and, in this regard, may positively interact with the intestinal microbiome and provide novel therapeutic solutions for intra-intestinal and extra-intestinal inflammatory conditions. View Full-Text
Keywords: bioactive; Perna canaliculus; green mussel; prebiotics; functional foods; intestinal microbiome bioactive; Perna canaliculus; green mussel; prebiotics; functional foods; intestinal microbiome
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Saltzman, E.T.; Thomsen, M.; Hall, S.; Vitetta, L. Perna canaliculus and the Intestinal Microbiome. Mar. Drugs 2017, 15, 207.

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