Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
by
Amy E. Wright 1,*
, K. Brian Killday 2, Debopam Chakrabarti 3, Esther A. Guzmán 1, Dedra Harmody 1, Peter J. McCarthy 1, Tara Pitts 1, Shirley A. Pomponi 1, John K. Reed 1, Bracken F. Roberts 3, Carolina Rodrigues Felix 3 and Kyle H. Rohde 3
, K. Brian Killday 2, Debopam Chakrabarti 3, Esther A. Guzmán 1, Dedra Harmody 1, Peter J. McCarthy 1, Tara Pitts 1, Shirley A. Pomponi 1, John K. Reed 1, Bracken F. Roberts 3, Carolina Rodrigues Felix 3 and Kyle H. Rohde 3
1
Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA
2
Bruker Biospin Corporation, Billerica, MA 01821, USA
3
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2017, 15(1), 16; https://doi.org/10.3390/md15010016
Received: 21 December 2016 / Accepted: 5 January 2017 / Published: 11 January 2017
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.
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Keywords:
bis(indole) alkaloid; Spongosorites; antibacterial; pancreatic cancer
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MDPI and ACS Style
Wright, A.E.; Killday, K.B.; Chakrabarti, D.; Guzmán, E.A.; Harmody, D.; McCarthy, P.J.; Pitts, T.; Pomponi, S.A.; Reed, J.K.; Roberts, B.F.; Rodrigues Felix, C.; Rohde, K.H. Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites. Mar. Drugs 2017, 15, 16.
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