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Open AccessFeature PaperArticle

Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites

1
Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA
2
Bruker Biospin Corporation, Billerica, MA 01821, USA
3
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2017, 15(1), 16; https://doi.org/10.3390/md15010016
Received: 21 December 2016 / Accepted: 5 January 2017 / Published: 11 January 2017
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. View Full-Text
Keywords: bis(indole) alkaloid; Spongosorites; antibacterial; pancreatic cancer bis(indole) alkaloid; Spongosorites; antibacterial; pancreatic cancer
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Wright, A.E.; Killday, K.B.; Chakrabarti, D.; Guzmán, E.A.; Harmody, D.; McCarthy, P.J.; Pitts, T.; Pomponi, S.A.; Reed, J.K.; Roberts, B.F.; Rodrigues Felix, C.; Rohde, K.H. Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites. Mar. Drugs 2017, 15, 16.

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