Next Article in Journal
Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis
Next Article in Special Issue
Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres
Previous Article in Journal
Anticancer Activity of a Hexapeptide from Skate (Raja porosa) Cartilage Protein Hydrolysate in HeLa Cells
Previous Article in Special Issue
Blue-Print Autophagy: Potential for Cancer Treatment
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(8), 154;

Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure

Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Academic Editors: Friedemann Honecker and Sergey A. Dyshlovoy
Received: 2 June 2016 / Revised: 17 July 2016 / Accepted: 9 August 2016 / Published: 16 August 2016
(This article belongs to the Special Issue Marine Compounds as Modulators of Autophagy and Lysosomal Activity)
Full-Text   |   PDF [1912 KB, uploaded 16 August 2016]   |  


Targeting autophagic pathways might play a critical role in designing novel chemotherapeutic approaches in the treatment of human cancers, and the prevention of tumor-derived chemoresistance. Marine compounds were found to decrease tumor cell growth in vitro and in vivo. Some of them were shown to induce autophagic flux in tumor cells. In this study, we observed that the selected marine life-derived compounds (Chromomycin A2, Psammaplin A, and Ilimaquinone) induce expression of several autophagic signaling intermediates in human squamous cell carcinoma, glioblastoma, and colorectal carcinoma cells in vitro through a transcriptional regulation by tumor protein (TP)-p53 family members. These conclusions were supported by specific qPCR expression analysis, luciferase reporter promoter assay, and chromatin immunoprecipitation of promoter sequences bound to the TP53 family proteins, and silencing of the TP53 members in tumor cells. View Full-Text
Keywords: marine drugs; cancer; autophagy; p53 family members; transcription marine drugs; cancer; autophagy; p53 family members; transcription

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Ratovitski, E.A. Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. Mar. Drugs 2016, 14, 154.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top