Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors

Hielscher-Michael, Stephanie; Griehl, Carola; Buchholz, Mirko; Demuth, Hans-Ulrich; Arnold, Norbert; Wessjohann, Ludger A.

doi:10.3390/md14110203

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Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors

Stephanie Hielscher-Michael

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Group Algae Biotechnology, Department of Applied Biosciences and Process Technology, Anhalt University of Applied Sciences, 06366 Köthen, Germany

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany

Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology IZI, 06120 Halle (Saale), Germany

Authors to whom correspondence should be addressed.

Academic Editor: Sadanandan E. Velu

Mar. Drugs 2016, 14(11), 203; https://doi.org/10.3390/md14110203

Received: 16 September 2016 / Revised: 20 October 2016 / Accepted: 25 October 2016 / Published: 2 November 2016

(This article belongs to the Special Issue Enzyme Inhibitors of Marine Origin)

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Abstract

In recent years, many new enzymes, like glutaminyl cyclase (QC), could be associated with pathophysiological processes and represent targets for many diseases, so that enzyme-inhibiting properties of natural substances are becoming increasingly important. In different studies, the pathophysiology connection of QC to various diseases including Alzheimer’s disease (AD) was described. Algae are known for the ability to synthesize complex and highly-diverse compounds with specific enzyme inhibition properties. Therefore, we screened different algae species for the presence of QC inhibiting metabolites using a new “Reverse Metabolomics” technique including an Activity-correlation Analysis (AcorA), which is based on the correlation of bioactivities to mass spectral data with the aid of mathematic informatics deconvolution. Thus, three QC inhibiting compounds from microalgae belonging to the family of sulfolipids were identified. The compounds showed a QC inhibition of 81% and 76% at concentrations of 0.25 mg/mL and 0.025 mg/mL, respectively. Thus, for the first time, sulfolipids are identified as QC inhibiting compounds and possess substructures with the required pharmacophore qualities. They represent a new lead structure for QC inhibitors. View Full-Text

Keywords: glutaminyl cyclase (QC) inhibitor; microalgae; sulfolipids; AD; reverse metabolomics; Scenedesmus sp.; natural product

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Hielscher-Michael, S.; Griehl, C.; Buchholz, M.; Demuth, H.-U.; Arnold, N.; Wessjohann, L.A. Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors. Mar. Drugs 2016, 14, 203. https://doi.org/10.3390/md14110203

AMA Style

Hielscher-Michael S, Griehl C, Buchholz M, Demuth H-U, Arnold N, Wessjohann LA. Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors. Marine Drugs. 2016; 14(11):203. https://doi.org/10.3390/md14110203

Chicago/Turabian Style

Hielscher-Michael, Stephanie, Carola Griehl, Mirko Buchholz, Hans-Ulrich Demuth, Norbert Arnold, and Ludger A. Wessjohann. 2016. "Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors" Marine Drugs 14, no. 11: 203. https://doi.org/10.3390/md14110203

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