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New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft

UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman
Marine Science and Fisheries Center, Ministry of Agriculture and Fisheries Resources, Muscat-113, Oman
Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, Nizwa-616, Oman
Authors to whom correspondence should be addressed.
Academic Editor: Sadanandan E. Velu
Mar. Drugs 2017, 15(1), 19;
Received: 3 November 2016 / Revised: 27 December 2016 / Accepted: 27 December 2016 / Published: 18 January 2017
(This article belongs to the Special Issue Enzyme Inhibitors of Marine Origin)
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In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound 1 was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound 1 showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation. View Full-Text
Keywords: Padina boergesenii; phytochemical investigation; structure elucidation; enzyme inhibition Padina boergesenii; phytochemical investigation; structure elucidation; enzyme inhibition

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Ali, L.; Khan, A.L.; Al-Broumi, M.; Al-Harrasi, R.; Al-Kharusi, L.; Hussain, J.; Al-Harrasi, A. New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft. Mar. Drugs 2017, 15, 19.

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