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Open AccessArticle

MDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078

Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, 18016 Armilla (Granada), Spain
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Academic Editor: Miguel O. Mitchell
Mar. Drugs 2016, 14(10), 188; https://doi.org/10.3390/md14100188
Received: 11 August 2016 / Revised: 29 September 2016 / Accepted: 13 October 2016 / Published: 18 October 2016
(This article belongs to the Special Issue Marine Organohalides)
A new napyradiomycin, MDN-0170 (1), was isolated from the culture broth of the marine-derived actinomycete strain CA-271078, together with three known related compounds identified as 4-dehydro-4a-dechloronapyradiomycin A1 (2), napyradiomycin A1 (3) and 3-chloro-6,8-dihydroxy-8-α-lapachone (4). The structure of the new compound was determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). The relative configuration of compound 1, which contains two independent stereoclusters, has been established by molecular modelling in combination with nOe and coupling constant analyses. Biosynthetic arguments also allowed us to propose its absolute stereochemistry. The antimicrobial properties of the compounds isolated were evaluated against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Aspergillus fumigatus, and Candida albicans. The potent bioactivity previously reported for compounds 2 and 3 against methicillin-sensitive S. aureus has been extended to methicillin-resistant strains in this report. View Full-Text
Keywords: Streptomyces; napyradiomycin; structural elucidation; antimicrobial activity Streptomyces; napyradiomycin; structural elucidation; antimicrobial activity
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Lacret, R.; Pérez-Victoria, I.; Oves-Costales, D.; De la Cruz, M.; Domingo, E.; Martín, J.; Díaz, C.; Vicente, F.; Genilloud, O.; Reyes, F. MDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078. Mar. Drugs 2016, 14, 188.

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