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Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres

Department of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, Spain
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, Spain
Authors to whom correspondence should be addressed.
Academic Editor: Hitoshi Sashiwa
Mar. Drugs 2015, 13(9), 5901-5919;
Received: 5 August 2015 / Revised: 8 September 2015 / Accepted: 9 September 2015 / Published: 16 September 2015
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan II, 2017)
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A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical and had a positive surface charge, which is an indicator of mucoadhesiveness. FTIR and X-ray diffraction results showed that there are not specific interactions of polyphenolic compounds in olive leaf extract with the chitosan matrix. Stability and release studies of chitosan microspheres loaded with olive leaf extract before and after the incorporation into a moisturizer base were performed. The resulting data showed that the developed formulations were stable up to three months. The encapsulation efficiency was around 44% and the release properties of polyphenols from the microspheres were found to be pH dependent. At pH 7.4, polyphenols release was complete after 6 h; whereas the amount of polyphenols released was 40% after the same time at pH 5.5. View Full-Text
Keywords: chitosan; spray-drying; semi-solid formulation; antioxidant encapsulation chitosan; spray-drying; semi-solid formulation; antioxidant encapsulation

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Acosta, N.; Sánchez, E.; Calderón, L.; Cordoba-Diaz, M.; Cordoba-Diaz, D.; Dom, S.; Heras, Á. Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres. Mar. Drugs 2015, 13, 5901-5919.

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