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Nitrogen-Containing Diterpenoids, Sesquiterpenoids, and Nor-Diterpenoids from Cespitularia taeniata

School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Mar. Drugs 2015, 13(9), 5796-5814;
Received: 13 August 2015 / Revised: 7 September 2015 / Accepted: 9 September 2015 / Published: 15 September 2015
PDF [566 KB, uploaded 15 September 2015]


Two new nitrogen-containing verticillene diterpenoids, cespilamides A and B (1 and 2), three new nitrogen-containing sesquiterpenoids, cespilamides C–E (35), and five new norverticillene and verticillene diterpenoids, cespitaenins A–E (610), were isolated from the Taiwanese soft coral Cespitularia taeniata. Compound 1 possesses an unusual oxazo ring system at C-10 while compound 2 displays an unprecedented C–C bond cleavage between C-10 and C-11 with an N-ethylphenyl group at C-10. Biogenetic pathways of 1 and 2 are proposed. The absolute configuration of 1 was confirmed by Mosher’s method and molecular mechanics calculations (MM2). The cytotoxicities of compounds 110 were evaluated against a small panel of human cancer cell lines. View Full-Text
Keywords: Cespitularia taeniata; verticillene diterpenoids; cytotoxicity Cespitularia taeniata; verticillene diterpenoids; cytotoxicity

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Wang, S.-S.; Cheng, Y.-B.; Lin, Y.-C.; Liaw, C.-C.; Chang, J.-Y.; Kuo, Y.-H.; Shen, Y.-C. Nitrogen-Containing Diterpenoids, Sesquiterpenoids, and Nor-Diterpenoids from Cespitularia taeniata. Mar. Drugs 2015, 13, 5796-5814.

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