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Mar. Drugs 2015, 13(8), 4594-4616;

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University
Author to whom correspondence should be addressed.
Academic Editor: Johannes F. Imhoff
Received: 2 June 2015 / Revised: 11 July 2015 / Accepted: 14 July 2015 / Published: 23 July 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)


Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development. View Full-Text
Keywords: deep-sea fungi; bioactive compounds; anticancer; antimicrobial; antiviral; antifungal deep-sea fungi; bioactive compounds; anticancer; antimicrobial; antiviral; antifungal

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, Y.-T.; Xue, Y.-R.; Liu, C.-H. A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi. Mar. Drugs 2015, 13, 4594-4616.

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