Next Article in Journal
Low-Molecular-Weight Metabolites from Diatoms: Structures, Biological Roles and Biosynthesis
Next Article in Special Issue
Characterization of Shrimp Oil from Pandalus borealis by High Performance Liquid Chromatography and High Resolution Mass Spectrometry
Previous Article in Journal
Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides
Previous Article in Special Issue
White Shrimp Litopenaeus vannamei That Have Received Gracilaria tenuistipitata Extract Show Early Recovery of Immune Parameters after Ammonia Stressing
Open AccessArticle

Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia

by Linlin Xu 1, Wenhong Dong 1, Jie Zhao 1 and Yajun Xu 1,2,*
1
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China
2
Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China
*
Author to whom correspondence should be addressed.
Academic Editor: Colin Barrow
Mar. Drugs 2015, 13(6), 3653-3671; https://doi.org/10.3390/md13063653
Received: 28 February 2015 / Revised: 21 May 2015 / Accepted: 1 June 2015 / Published: 5 June 2015
(This article belongs to the Special Issue Marine Functional Food)
Asphyxia during delivery produces long-term deficits in brain development. We investigated the neuroprotective effects of marine collagen peptides (MCPs), isolated from Chum Salmon skin by enzymatic hydrolysis, on male rats with perinatal asphyxia (PA). PA was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a water bath for 15 min. Caesarean-delivered pups were used as controls. PA rats were intragastrically administered with 0.33 g/kg, 1.0 g/kg and 3.0 g/kg body weight MCPs from postnatal day 0 (PND 0) till the age of 90-days. Behavioral tests were carried out at PND21, PND 28 and PND 90. The results indicated that MCPs facilitated early body weight gain of the PA pups, however had little effects on early physiological development. Behavioral tests revealed that MCPs facilitated long-term learning and memory of the pups with PA through reducing oxidative damage and acetylcholinesterase (AChE) activity in the brain, and increasing hippocampus phosphorylated cAMP-response element binding protein (p-CREB) and brain derived neurotrophic factor (BDNF) expression. View Full-Text
Keywords: marine collagen peptides; perinatal asphyxia; neurobehavioral development marine collagen peptides; perinatal asphyxia; neurobehavioral development
Show Figures

Figure 1

MDPI and ACS Style

Xu, L.; Dong, W.; Zhao, J.; Xu, Y. Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia. Mar. Drugs 2015, 13, 3653-3671.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop