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Open AccessArticle

Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A

by Ying Fu 1,2,3, Ping Wu 1,2, Jinghua Xue 1,2, Hanxiang Li 1,2,* and Xiaoyi Wei 1,2
1
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China
2
Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China
3
University of Chinese Academy of Sciences, Yuquanlu 19A, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Mar. Drugs 2015, 13(6), 3360-3367; https://doi.org/10.3390/md13063360
Received: 18 April 2015 / Accepted: 20 May 2015 / Published: 27 May 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
Two new quinone sesquiterpenes named myrothecols G and H (1 and 2), a pair of C-1′ diastereomers of 13-hydroxyl penicilliumin A, were isolated from the mycelia solid cultures of Myrothecium sp. SC0265. Their structures, including the absolute configurations, were established on the basis of the spectroscopic data combining with the theoretical conformational analysis. The cytotoxic activities of 1 and 2 were tested against a panel of human tumor cell lines. View Full-Text
Keywords: 13-hydroxyl penicilliumin A; myrothecol G; myrothecol H; quinone sesquiterpenes; stereochemistry; theoretical conformational analysis; cytotoxicity 13-hydroxyl penicilliumin A; myrothecol G; myrothecol H; quinone sesquiterpenes; stereochemistry; theoretical conformational analysis; cytotoxicity
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Fu, Y.; Wu, P.; Xue, J.; Li, H.; Wei, X. Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A. Mar. Drugs 2015, 13, 3360-3367.

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