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Open AccessArticle

Alginate Hydrogels Coated with Chitosan for Wound Dressing

Institute for Polymers, Composites and Biomaterials (IPCB), CNR, via Campi Flegrei 34, Pozzuoli 80078, Italy
Institute of Biomolecular Chemistry, CNR, via Campi Flegrei 34, Pozzuoli 80078, Italy
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, via L. De Crecchio 7, Naples 80138, Italy
Author to whom correspondence should be addressed.
Academic Editor: Alejandro M. Mayer
Mar. Drugs 2015, 13(5), 2890-2908;
Received: 24 February 2015 / Revised: 2 April 2015 / Accepted: 29 April 2015 / Published: 11 May 2015
(This article belongs to the Collection Marine Polysaccharides)
PDF [2607 KB, uploaded 13 May 2015]


In this work, a coating of chitosan onto alginate hydrogels was realized using the water-soluble hydrochloride form of chitosan (CH-Cl), with the dual purpose of imparting antibacterial activity and delaying the release of hydrophilic molecules from the alginate matrix. Alginate hydrogels with different calcium contents were prepared by the internal setting method and coated by immersion in a CH-Cl solution. Structural analysis by cryo-scanning electron microscopy was carried out to highlight morphological alterations due to the coating layer. Tests in vitro with human mesenchymal stromal cells (MSC) were assessed to check the absence of toxicity of CH-Cl. Swelling, stability in physiological solution and release characteristics using rhodamine B as the hydrophilic model drug were compared to those of relative uncoated hydrogels. Finally, antibacterial activity against Escherichia coli was tested. Results show that alginate hydrogels coated with chitosan hydrochloride described here can be proposed as a novel medicated dressing by associating intrinsic antimicrobial activity with improved sustained release characteristics. View Full-Text
Keywords: chitosan hydrochloride; alginate; hydrogels; antibacterial activity; sustained release; wound dressing chitosan hydrochloride; alginate; hydrogels; antibacterial activity; sustained release; wound dressing

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Straccia, M.C.; D'Ayala, G.G.; Romano, I.; Oliva, A.; Laurienzo, P. Alginate Hydrogels Coated with Chitosan for Wound Dressing. Mar. Drugs 2015, 13, 2890-2908.

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