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Mar. Drugs 2015, 13(2), 1051-1067;

Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells

Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea
Department of Life Science, Gachon University, Seongnam 461-701, Korea
Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Hwasung 445-760, Korea
Division of Information Analysis Research, Korea Institute of Science and Technology Information, KISTI, Seoul 130-741, Korea
The Clinical Center for Bio-industry, Semyung University, Jecheon, 390-711, Korea
Department of Physical Therapy, Kangwon National University, Gangwon-do 245-711, Korea
Authors to whom correspondence should be addressed.
These authors are equally contributed to this work.
Academic Editor: Colin Barrow
Received: 31 December 2014 / Revised: 30 January 2015 / Accepted: 10 February 2015 / Published: 16 February 2015
(This article belongs to the Special Issue Marine Functional Food)
Full-Text   |   PDF [625 KB, uploaded 24 February 2015]   |  


Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-β1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-β1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions. View Full-Text
Keywords: fucoidan; transforming growth factor beta 1; cyclooxygenase-2; alcohol; liver fucoidan; transforming growth factor beta 1; cyclooxygenase-2; alcohol; liver

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Lim, J.D.; Lee, S.R.; Kim, T.; Jang, S.-A.; Kang, S.C.; Koo, H.J.; Sohn, E.; Bak, J.P.; Namkoong, S.; Kim, H.K.; Song, I.S.; Kim, N.; Sohn, E.-H.; Han, J. Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells. Mar. Drugs 2015, 13, 1051-1067.

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