Mar. Drugs 2015, 13(10), 6274-6290; https://doi.org/10.3390/md13106274
Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
1
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
2
Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA
3
Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 13 August 2015 / Revised: 25 September 2015 / Accepted: 25 September 2015 / Published: 9 October 2015
Abstract
A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue. View Full-TextKeywords:
macrolactone; polyketide; cyanobacteria; chemotaxis; cell cycle
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Mori, S.; Williams, H.; Cagle, D.; Karanovich, K.; Horgen, F.D.; III, R.S.; Watanabe, C.M.H. Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity. Mar. Drugs 2015, 13, 6274-6290.
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