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Article

Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

1
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
2
Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA
3
Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Mar. Drugs 2015, 13(10), 6274-6290; https://doi.org/10.3390/md13106274
Received: 13 August 2015 / Revised: 25 September 2015 / Accepted: 25 September 2015 / Published: 9 October 2015
A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue. View Full-Text
Keywords: macrolactone; polyketide; cyanobacteria; chemotaxis; cell cycle macrolactone; polyketide; cyanobacteria; chemotaxis; cell cycle
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MDPI and ACS Style

Mori, S.; Williams, H.; Cagle, D.; Karanovich, K.; Horgen, F.D.; III, R.S.; Watanabe, C.M.H. Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity. Mar. Drugs 2015, 13, 6274-6290. https://doi.org/10.3390/md13106274

AMA Style

Mori S, Williams H, Cagle D, Karanovich K, Horgen FD, III RS, Watanabe CMH. Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity. Marine Drugs. 2015; 13(10):6274-6290. https://doi.org/10.3390/md13106274

Chicago/Turabian Style

Mori, Shogo, Howard Williams, Davey Cagle, Kristopher Karanovich, F. D. Horgen, Roger S. III, and Coran M.H. Watanabe. 2015. "Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity" Marine Drugs 13, no. 10: 6274-6290. https://doi.org/10.3390/md13106274

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