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Mar. Drugs 2015, 13(10), 6247-6258;

Mycemycins A–E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
University of Chinese Academy of Sciences, Beijing 100049, China
Analytical and Testing Center, Beijing University of Chemical Technology, Beijing 100029, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 25 July 2015 / Revised: 17 September 2015 / Accepted: 18 September 2015 / Published: 30 September 2015
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Five new dibenzoxazepinone derivatives, mycemycins A–E (15), were isolated from the ethanol extracts of mycelia of two different streptomycetes. 1 and 2 were isolated from an acidic red soil-derived strain, Streptomyces sp. FXJ1.235, and 35 from a gntR gene-disrupted deep-sea strain named Streptomyces olivaceus FXJ8.012Δ1741. The structures of mycemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques. View Full-Text
Keywords: mycemycin; dibenzoxazepinone; deep-sea; Streptomyces; gene disruption mycemycin; dibenzoxazepinone; deep-sea; Streptomyces; gene disruption

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Liu, N.; Song, F.; Shang, F.; Huang, Y. Mycemycins A–E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes. Mar. Drugs 2015, 13, 6247-6258.

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