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Potent Cytotoxic Peptides from the Australian Marine Sponge Pipestela candelabra

Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia
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Mar. Drugs 2014, 12(6), 3399-3415; https://doi.org/10.3390/md12063399
Received: 4 March 2014 / Revised: 10 April 2014 / Accepted: 14 April 2014 / Published: 4 June 2014
Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human prostate cancer cells (PC3) compared to the human neonatal foreskin fibroblast non-cancer cells (NFF). Twelve secondary metabolites were isolated in which four compounds are new small peptides. Their structures were characterized by spectroscopic and chemical analysis. These compounds inhibited selectively the growth of prostate cancer cells with IC50 values in the picomolar to sub-micromolar range. Structure-activity relationship of these compounds is discussed. View Full-Text
Keywords: Pipestela candelabra; cytotoxicity; peptide; milnamide; hemiasterlin; geodiamolide; prostate cancer Pipestela candelabra; cytotoxicity; peptide; milnamide; hemiasterlin; geodiamolide; prostate cancer
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Tran, T.D.; Pham, N.B.; Fechner, G.A.; Hooper, J.N.A.; Quinn, R.J. Potent Cytotoxic Peptides from the Australian Marine Sponge Pipestela candelabra. Mar. Drugs 2014, 12, 3399-3415.

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