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Open AccessArticle

New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
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These authors contributed equally to this work.
Mar. Drugs 2014, 12(6), 3190-3202; https://doi.org/10.3390/md12063190
Received: 1 April 2014 / Revised: 3 May 2014 / Accepted: 5 May 2014 / Published: 28 May 2014
Four new prenylxanthones, emerixanthones A–D (14), together with six known analogues (510), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens. View Full-Text
Keywords: prenylxanthone; Emericella; deep-sea; fungus prenylxanthone; Emericella; deep-sea; fungus
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Fredimoses, M.; Zhou, X.; Lin, X.; Tian, X.; Ai, W.; Wang, J.; Liao, S.; Liu, J.; Yang, B.; Yang, X.; Liu, Y. New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240. Mar. Drugs 2014, 12, 3190-3202.

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