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Marine Drugs
Volume 12
Issue 4
10.3390/md12042054
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Open AccessArticle

Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.

by
Hiyoung Kim
1,†,
Kwang-Jin Kim
2,†,
Jeong-Tae Yeon
3,
Seong Hwan Kim
4,
Dong Hwan Won
1,
Hyukjae Choi
5,
Sang-Jip Nam
6,
Young-Jin Son
2,* and
Heonjoong Kang
1,7,*
1
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea
2
Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea
3
Research Institute of Basic Science, Sunchon National University, Suncheon 540-742, Korea
4
Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea
5
College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea
6
Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea
7
Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2014, 12(4), 2054-2065; https://doi.org/10.3390/md12042054
Received: 10 February 2014 / Revised: 28 February 2014 / Accepted: 19 March 2014 / Published: 3 April 2014
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Abstract

A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively. View Full-Text
Keywords: Placospongia; sponge; RANKL; osteoclasts Placospongia; sponge; RANKL; osteoclasts
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MDPI and ACS Style

Kim, H.; Kim, K.-J.; Yeon, J.-T.; Kim, S.H.; Won, D.H.; Choi, H.; Nam, S.-J.; Son, Y.-J.; Kang, H. Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. Mar. Drugs 2014, 12, 2054-2065. https://doi.org/10.3390/md12042054

AMA Style

Kim H, Kim K-J, Yeon J-T, Kim SH, Won DH, Choi H, Nam S-J, Son Y-J, Kang H. Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. Marine Drugs. 2014; 12(4):2054-2065. https://doi.org/10.3390/md12042054

Chicago/Turabian Style

Kim, Hiyoung; Kim, Kwang-Jin; Yeon, Jeong-Tae; Kim, Seong H.; Won, Dong H.; Choi, Hyukjae; Nam, Sang-Jip; Son, Young-Jin; Kang, Heonjoong. 2014. "Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp." Mar. Drugs 12, no. 4: 2054-2065. https://doi.org/10.3390/md12042054

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