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Mar. Drugs 2014, 12(2), 601-635;

Targeting Nuclear Receptors with Marine Natural Products

State Key Laboratory of Cellular Stress Biology, Innovation Center of Cell Biology Research, School of Life Sciences, Xiamen University, Xiamen 361102, China
Authors to whom correspondence should be addressed.
Received: 12 November 2013 / Revised: 20 December 2013 / Accepted: 7 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Mechanism of Action Analysis for Marine Compounds)
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Nuclear receptors (NRs) are important pharmaceutical targets because they are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis. As ligands play a pivotal role in modulating nuclear receptor activity, the discovery of novel ligands for nuclear receptors represents an interesting and promising therapeutic approach. The search for novel NR agonists and antagonists with enhanced selectivities prompted the exploration of the extraordinary chemical diversity associated with natural products. Recent studies involving nuclear receptors have disclosed a number of natural products as nuclear receptor ligands, serving to re-emphasize the translational possibilities of natural products in drug discovery. In this review, the natural ligands of nuclear receptors will be described with an emphasis on their mechanisms of action and their therapeutic potentials, as well as on strategies to determine potential marine natural products as nuclear receptor modulators. View Full-Text
Keywords: nuclear receptors; marine natural products; ligands; screen; drug targets nuclear receptors; marine natural products; ligands; screen; drug targets

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Yang, C.; Li, Q.; Li, Y. Targeting Nuclear Receptors with Marine Natural Products. Mar. Drugs 2014, 12, 601-635.

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