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Characterisation of Non-Autoinducing Tropodithietic Acid (TDA) Production from Marine Sponge Pseudovibrio Species

BIOMERIT Research Centre, School of Microbiology, University College Cork—National University of Ireland, Cork, Ireland
Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, Bremen D-28359, Germany
Jacobs University Bremen gGmbH, Bremen 28759, Germany
Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
Environmental Research Institute, University College Cork—National University of Ireland, Cork, Ireland
Curtin University, School of Biomedical Sciences, Perth, WA 6845, Australia
Author to whom correspondence should be addressed.
Current Address: Maastricht University Medical Centre, 6211 LK Maastricht, The Netherlands
Mar. Drugs 2014, 12(12), 5960-5978;
Received: 15 September 2014 / Revised: 5 November 2014 / Accepted: 12 November 2014 / Published: 10 December 2014
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The search for new antimicrobial compounds has gained added momentum in recent years, paralleled by the exponential rise in resistance to most known classes of current antibiotics. While modifications of existing drugs have brought some limited clinical success, there remains a critical need for new classes of antimicrobial compound to which key clinical pathogens will be naive. This has provided the context and impetus to marine biodiscovery programmes that seek to isolate and characterize new activities from the aquatic ecosystem. One new antibiotic to emerge from these initiatives is the antibacterial compound tropodithietic acid (TDA). The aim of this study was to provide insight into the bioactivity of and the factors governing the production of TDA in marine Pseudovibrio isolates from a collection of marine sponges. The TDA produced by these Pseudovibrio isolates exhibited potent antimicrobial activity against a broad spectrum of clinical pathogens, while TDA tolerance was frequent in non-TDA producing marine isolates. Comparative genomics analysis suggested a high degree of conservation among the tda biosynthetic clusters while expression studies revealed coordinated regulation of TDA synthesis upon transition from log to stationary phase growth, which was not induced by TDA itself or by the presence of the C10-acyl homoserine lactone quorum sensing signal molecule. View Full-Text
Keywords: TDA; Pseudovibrio; marine; antimicrobial; clinical TDA; Pseudovibrio; marine; antimicrobial; clinical

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Harrington, C.; Reen, F.J.; Mooij, M.J.; Stewart, F.A.; Chabot, J.-B.; Guerra, A.F.; Glöckner, F.O.; Nielsen, K.F.; Gram, L.; Dobson, A.D.W.; Adams, C.; O'Gara, F. Characterisation of Non-Autoinducing Tropodithietic Acid (TDA) Production from Marine Sponge Pseudovibrio Species. Mar. Drugs 2014, 12, 5960-5978.

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