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Open AccessCommunication

Butrepyrazinone, a New Pyrazinone with an Unusual Methylation Pattern from a Ghanaian Verrucosispora sp. K51G

Marine and Plant Laboratory of Ghana, Department of Chemistry, University of Ghana, Accra, P.O. Box LG 56, Ghana
Department of Bioengineering, Faculty of Engineering, Tunceli University, 62000 Tunceli, Turkey
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, AB24 3UE, Scotland, UK
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Authors to whom correspondence should be addressed.
Mar. Drugs 2014, 12(10), 5197-5208;
Received: 4 August 2014 / Revised: 25 September 2014 / Accepted: 28 September 2014 / Published: 16 October 2014
We report the structural characterization of a new pyrazinone analogue; butrepyrazinone, which was isolated from a new actinomycete strain Verrucosispora sp. K51G recovered from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of a compound from the fermentation culture and a combination of NMR spectroscopy, high-resolution mass spectrometry and computer-aided calculations revealed that butrepyrazinone (10) possesses an unusual methylation pattern on the pyrazinone ring. Butrepyrazinone (10), however, displayed no antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains, suggesting that 10 may act as a signal molecule for this strain. Although the same molecule has been synthesized previously, this is the first report to disclose the discovery of butrepyrazinone (10) from nature. View Full-Text
Keywords: micromonosporaceae; actinomycete; pyrazinone; mangrove micromonosporaceae; actinomycete; pyrazinone; mangrove
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Kyeremeh, K.; Acquah, K.S.; Camas, M.; Tabudravu, J.; Houssen, W.; Deng, H.; Jaspars, M. Butrepyrazinone, a New Pyrazinone with an Unusual Methylation Pattern from a Ghanaian Verrucosispora sp. K51G. Mar. Drugs 2014, 12, 5197-5208.

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