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Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source

1
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
2
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
3
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China
4
Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(1), 167-175; https://doi.org/10.3390/md12010167
Received: 1 November 2013 / Revised: 2 December 2013 / Accepted: 12 December 2013 / Published: 7 January 2014
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Abstract

Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM. View Full-Text
Keywords: marine fungus; Chondrostereum sp.; sesquiterpenoids; chondrosterins; cytotoxic activity marine fungus; Chondrostereum sp.; sesquiterpenoids; chondrosterins; cytotoxic activity
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Li, H.-J.; Jiang, W.-H.; Liang, W.-L.; Huang, J.-X.; Mo, Y.-F.; Ding, Y.-Q.; Lam, C.-K.; Qian, X.-J.; Zhu, X.-F.; Lan, W.-J. Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source. Mar. Drugs 2014, 12, 167-175.

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