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Keywords = chondrosterins

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9 pages, 1664 KB  
Article
Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp.
by Lei Huang, Wen-Jian Lan, Rong Deng, Gong-Kan Feng, Qing-Yan Xu, Zhi-Yu Hu, Xiao-Feng Zhu and Hou-Jin Li
Mar. Drugs 2016, 14(9), 157; https://doi.org/10.3390/md14090157 - 26 Aug 2016
Cited by 21 | Viewed by 7468
Abstract
By the method of 1H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids—chondrosterins K–M (13) and the known sesquiterpenoid anhydroarthrosporone (4)—were isolated from the marine fungus Chondrostereum [...] Read more.
By the method of 1H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids—chondrosterins K–M (13) and the known sesquiterpenoid anhydroarthrosporone (4)—were isolated from the marine fungus Chondrostereum sp. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Chondrosterin K is a rare hirsutane sesquiterpenoid, in which a methyl group was migrated from C-2 to C-6 and has a double bond between C-2 and C-3. Compounds 13 showed significant cytotoxicities against various cancer cell lines in vitro. Full article
(This article belongs to the Special Issue Marine Fungal Natural Products)
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9 pages, 877 KB  
Communication
Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source
by Hou-Jin Li, Wen-Han Jiang, Wan-Ling Liang, Jia-Xin Huang, Yu-Fei Mo, Yan-Qing Ding, Chi-Keung Lam, Xiao-Jun Qian, Xiao-Feng Zhu and Wen-Jian Lan
Mar. Drugs 2014, 12(1), 167-175; https://doi.org/10.3390/md12010167 - 7 Jan 2014
Cited by 34 | Viewed by 8498
Abstract
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as [...] Read more.
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM. Full article
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8 pages, 543 KB  
Article
Isolation and Structural Elucidation of Chondrosterins F–H from the Marine Fungus Chondrostereum sp.
by Hou-Jin Li, Ting Chen, Ying-Lu Xie, Wen-Dan Chen, Xiao-Feng Zhu and Wen-Jian Lan
Mar. Drugs 2013, 11(2), 551-558; https://doi.org/10.3390/md11020551 - 22 Feb 2013
Cited by 35 | Viewed by 8756
Abstract
The marine fungus Chondrostereum sp. was collected from a soft coral of the species Sarcophyton tortuosum from the South China Sea. Three new compounds, chondrosterins F–H (1, 4 and 5), together with three known compounds, incarnal (2), arthrosporone [...] Read more.
The marine fungus Chondrostereum sp. was collected from a soft coral of the species Sarcophyton tortuosum from the South China Sea. Three new compounds, chondrosterins F–H (1, 4 and 5), together with three known compounds, incarnal (2), arthrosporone (3), and (2E)-decene-4,6,8-triyn-1-ol (6), were isolated. Their structures were elucidated primarily based on NMR and MS data. Incarnal (2) exhibited potent cytotoxic activity against various cancer cell lines. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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12 pages, 738 KB  
Article
Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.
by Hou-Jin Li, Ying-Lu Xie, Zhong-Liang Xie, Ying Chen, Chi-Keung Lam and Wen-Jian Lan
Mar. Drugs 2012, 10(3), 627-638; https://doi.org/10.3390/md10030627 - 13 Mar 2012
Cited by 61 | Viewed by 9675
Abstract
The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (1 [...] Read more.
The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (15), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 μM, respectively. Full article
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