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Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology

1
Division of Magnetic Resonance, Korea Basic Scienc Institute, Chungbuk 363-833, Korea
2
Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 406-840, Korea
3
Department of Polar Sciences, University of Science and Technology, Incheon 406-840, Korea
4
Division of Polar Climate Research, Korea Polar Research Institute, Incheon 406-840, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2013, 11(6), 2013-2041; https://doi.org/10.3390/md11062013
Received: 1 April 2013 / Revised: 22 April 2013 / Accepted: 10 May 2013 / Published: 10 June 2013
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore essential to the survival of many marine teleost fishes that routinely encounter sub-zero temperatures. Owing to this property, AF(G)Ps have potential applications in many areas such as storage of cells or tissues at low temperature, ice slurries for refrigeration systems, and food storage. In contrast to AFGPs, which are composed of repeated tripeptide units (Ala-Ala-Thr)n with minor sequence variations, AFPs possess very different primary, secondary, and tertiary structures. The isolation and purification of AFGPs is laborious, costly, and often results in mixtures, making characterization difficult. Recent structural investigations into the mechanism by which linear and cyclic AFGPs inhibit ice crystallization have led to significant progress toward the synthesis and assessment of several synthetic mimics of AFGPs. This review article will summarize synthetic AFGP mimics as well as current challenges in designing compounds capable of mimicking AFGPs. It will also cover our recent efforts in exploring whether peptoid mimics can serve as structural and functional mimics of native AFGPs. View Full-Text
Keywords: antifreeze glycopeptide; antifreeze protein; recrystallization inhibition; thermal hysteresis antifreeze glycopeptide; antifreeze protein; recrystallization inhibition; thermal hysteresis
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Bang, J.K.; Lee, J.H.; Murugan, R.N.; Lee, S.G.; Do, H.; Koh, H.Y.; Shim, H.-E.; Kim, H.-C.; Kim, H.J. Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology. Mar. Drugs 2013, 11, 2013-2041.

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