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Mar. Drugs 2013, 11(11), 4294-4317;

Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides

Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d'Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France
Food Neurotoxicology, Micropollutants and Food Contaminants (MRCA), University of Lorraine, Research Unit on Animal and Functionality of Animal Products (URAFPA), Institut National de la Recherche Agronomique (INRA), BP 4102, Metz 57040, France
Le Stum Laboratory, Larmor Plage 56260, France
Author to whom correspondence should be addressed.
Received: 17 July 2013 / Revised: 20 August 2013 / Accepted: 22 August 2013 / Published: 30 October 2013
(This article belongs to the Special Issue Marine Fatty Acids-2013)
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A phospholipopeptidic complex obtained by the enzymatic hydrolysis of salmon heads in green conditions; exert anxiolytic-like effects in a time and dose-dependent manner, with no affection of locomotor activity. This study focused on the physico-chemical properties of the lipidic and peptidic fractions from this natural product. The characterization of mineral composition, amino acid and fatty acids was carried out. Stability of nanoemulsions allowed us to realize a behavioral study conducted with four different tests on 80 mice. This work highlighted the dose dependent effects of the natural complex and its various fractions over a period of 14 days compared to a conventional anxiolytic. The intracellular redox status of neural cells was evaluated in order to determine the free radicals scavenging potential of these products in the central nervous system (CNS), after mice sacrifice. The complex peptidic fraction showed a strong scavenging property and similar results were found for the complex as well as its lipidic fraction. For the first time, the results of this study showed the anxiolytic-like and neuroprotective properties of a phospholipopeptidic complex extracted from salmon head. The applications on anxiety disorders might be relevant, depending on the doses, the fraction used and the chronicity of the supplementation. View Full-Text
Keywords: nanoemulsion; anti-anxiety activity; PUFA; reactive oxygen species; neuroprotective effect nanoemulsion; anti-anxiety activity; PUFA; reactive oxygen species; neuroprotective effect

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Belhaj, N.; Desor, F.; Gleizes, C.; Denis, F.M.; Arab-Tehrany, E.; Soulimani, R.; Linder, M. Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides. Mar. Drugs 2013, 11, 4294-4317.

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