Next Article in Journal
Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012
Next Article in Special Issue
Screening Mangrove Endophytic Fungi for Antimalarial Natural Products
Previous Article in Journal
Red Algal Bromophenols as Glucose 6-Phosphate Dehydrogenase Inhibitors
Previous Article in Special Issue
Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2013, 11(10), 4058-4082;

Trypanocidal Activity of Marine Natural Products

Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane 4111, Australia
Author to whom correspondence should be addressed.
Received: 16 August 2013 / Revised: 9 October 2013 / Accepted: 10 October 2013 / Published: 22 October 2013
(This article belongs to the Special Issue Antiprotozoal Marine Natural Products)
Full-Text   |   PDF [1043 KB, uploaded 24 February 2015]   |  


Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human African trypanosomiasis and Chagas disease, for which very few drugs are currently available. This article will review the marine natural products for which activity against the kinetoplastid parasites; Trypanosoma brucei brucei, T.b. rhodesiense and T. cruzi has been reported. As it is important to know the selectivity of a compound when evaluating its trypanocidal activity, this article will only cover molecules which have simultaneously been tested for cytotoxicity against a mammalian cell line. Compounds have been grouped according to their chemical structure and representative examples from each class were selected for detailed discussion. View Full-Text
Keywords: human African trypanosomiasis; sleeping sickness; chagas disease; marine natural products; drug discovery human African trypanosomiasis; sleeping sickness; chagas disease; marine natural products; drug discovery

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Jones, A.J.; Grkovic, T.; Sykes, M.L.; Avery, V.M. Trypanocidal Activity of Marine Natural Products. Mar. Drugs 2013, 11, 4058-4082.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top